Cricket South Africa has chosen to rest Dale Steyn and Quinton de Kock from the Proteas squad for the first two ODIs against Pakistan.
Aiden Markram is set to make a return to the squad while there is also a call-up for the Knights bowler Duanne Olivier.
The first ODI against Pakistan will be played at St Georges Park in Port Elizabeth on Saturday with a new squad expected to be named for the final three ODIs of the series.
Proteas squad:
Faf du Plessis (Titans, captain), Hashim Amla (Cape Cobras), Reeza Hendricks (Highveld Lions), Imran Tahir (Dolphins), Heinrich Klaasen (Titans), Aiden Markram (Titans), David Miller (Dolphins), Duanne Olivier (Knights) Dane Paterson (Cape Cobras), Andile Phehlukwayo (Dolphins), Dwaine Pretorius (Highveld Lions), Kagiso Rabada (Highveld Lions), Tabraiz Shamsi (Titans), Rassie van der Dussen (Highveld Lions).