Enyimba qualified 5-1 on aggregate and face Al Hilal of Sudan next month for a place in the group phase
Raja have been overshadowed in recent years by neighbours and fierce rivals Wydad Cssablanca
Esperance, who retained their title won in 2018, were fined $50,000 over the use of smoke bombs and projectiles
Reports in Tunisia said officials were aware that the VAR system was not working, but the players probably did not know.
Esperance are the first club to win the competition twice without losing a match.
Grisha is suspended for six months after a complaint made by the Moroccan Football Federation
Wydad and Esperance meet again next Friday in the Tunis suburb of Rades to decide who wins the elite African club competition
Wydad will host Esperance on May 24 or 25 with the return match on May 31 or June
Losing by four goals on aggregate equalled the worst performance by Ahly in Africa
The victory gives Etoile some breathing space heading into the quarter-final second-leg against Al-Hilal